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Article

NQO1 promotes an aggressive phenotype in hepatocellular carcinoma via amplifying ERK-NRF2 signaling.

Cancer science - 1 Feb 2021

Yang Yun, Zheng Jie, Wang Mengchao, Zhang Jin, Tian Tao, Wang Zhiheng, Yuan Shengxian, Liu Lei, Zhu Peng, Gu Fangming, Fu Siyuan, Shan Yunfeng, Pan Zeya, Zhou Weiping

Abstract excerpt

Patients with hepatocellular carcinoma (HCC) are usually diagnosed at the later stages and have poor survival outcomes. New molecules are urgently needed for the prognostic predication and individual treatment. Our study showed that high levels of NQO1 expression frequently exist in HCC with an obvious cancer-specific pattern. Patients with NQO1-high tumors are significantly associated with poor survival outcomes...

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Identifiers

PMID: 33222332
DOI: 10.1111/cas.14744
PMCID: PMC7894015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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