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Article

Lamin‑B1 is a senescence‑associated biomarker in clear‑cell renal cell carcinoma

9 Jul 2019

Abstract excerpt

Clear‑cell renal cell carcinoma (ccRCC) is a von‑Hippel‑Lindau gene (VHL) associated tumor disease. In addition to activating the hypoxia inducible factor (HIF) dependent oxygen‑sensing pathway, VHL loss also has an impact on a HIF‑independent senescence program which functions as a tumorigenesis barrier. Lamin‑B1 is a nuclear intermediate filament protein that exhibits effects on chromatin structure and gene...

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PMID: 31402955
DOI: 10.3892/ol.2019.10593

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