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Article

A STAT3-based gene signature stratifies glioma patients for targeted therapy

9 Aug 2019

Abstract excerpt

Intratumoral heterogeneity is a hallmark of glioblastoma (GBM) tumors, thought to negatively influence therapeutic outcome. Previous studies showed that mesenchymal tumors have a worse outcome than the proneural subtype. Here we focus on STAT3 as its activation precedes the proneural-mesenchymal transition. We first establish a STAT3 gene signature that stratifies GBM patients into STAT3-high and -low cohorts....

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PMID: 31399589
DOI: 10.1038/s41467-019-11614-x

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