Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

O-GlcNAcylated c-Jun antagonizes ferroptosis via inhibiting GSH synthesis in liver cancer

5 Aug 2019

Abstract excerpt

Ferroptosis is a metabolism-related cell death. Stimulating ferroptosis in liver cancer cells is a strategy to treat liver cancer. However, how to eradicate liver cancer cells through ferroptosis and the obstacles to inducing ferroptosis in liver cancer remain unclear. Here, we observed that erastin suppressed the malignant phenotypes of liver cancer cells by inhibiting O-GlcNAcylation of c-Jun and further...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Ferroptosis and cancer prognosis
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31394193
DOI: 10.1016/j.cellsig.2019.109384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

O-GlcNAcylated c-Jun antagonizes ferroptosis via inhibiting GSH synthesis in liver cancerPMID 31394193Read ↗

Ferroptosis is governed by differential regulation of transcription in liver cancerSemantic proximity Read ↗

Suppressing circIDE/miR-19b-3p/RBMS1 axis exhibits promoting-tumour activity through upregulating GPX4 to diminish ferroptosis in hepatocellular carcinomaSemantic proximity Read ↗

MicroRNA‐214‐3p enhances erastin‐induced ferroptosis by targeting ATF4 in hepatoma cellsSemantic proximity Read ↗

O-GlcNAcylation enhances sensitivity to RSL3-induced ferroptosis via the YAP/TFRC pathway in liver cancerSemantic proximity Read ↗

ACTL6A protects gastric cancer cells against ferroptosis through induction of glutathione synthesisSemantic proximity Read ↗

CircRNA-ST6GALNAC6 increases the sensitivity of bladder cancer cells to erastin-induced ferroptosis by regulating the HSPB1/P38 axisSemantic proximity Read ↗

GINS4 suppresses ferroptosis by antagonizing p53 acetylation with SnailSemantic proximity Read ↗

Amarogentin suppresses cell proliferation and EMT process through inducing ferroptosis in colorectal cancerSemantic proximity Read ↗

HSPA5 repressed ferroptosis to promote colorectal cancer development by maintaining GPX4 stabilitySemantic proximity Read ↗

Regulatory factor X1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by transcriptional regulation of BECN1Semantic proximity Read ↗

Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathwaySemantic proximity Read ↗

Hypoxia protects H9c2 cells against Ferroptosis through SENP1-mediated protein DeSUMOylationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.