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HSPA5 repressed ferroptosis to promote colorectal cancer development by maintaining GPX4 stability

1 Jan 2022

Abstract excerpt

Colorectal cancer (CRC) is one of the most malignant cancers and its pathological mechanism is largely unknown. Unfolded protein response and ferroptosis are both critical factors involved in CRC development. However, their relationship in CRC remains to be explored. In this study, erastin was used to induce ferroptosis in CRC cells. Ferroptosis was confirmed by the detection of glutathione, malondialdehyde, and...

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PMID: 35723198
DOI: 10.4149/neo_2022_220331n363

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