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ACTL6A protects gastric cancer cells against ferroptosis through induction of glutathione synthesis

13 Jul 2023

Abstract excerpt

Gastric cancer (GC), one of the most common malignant tumors in the world, exhibits a rapid metastasis rate and causes high mortality. Diagnostic markers and potential therapeutic targets for GCs are urgently needed. Here we show that Actin-like protein 6 A (ACTL6A), encoding an SWI/SNF subunit, is highly expressed in GCs. ACTL6A is found to be critical for regulating the glutathione (GSH) metabolism pathway...

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PMID: 37443154
DOI: 10.1038/s41467-023-39901-8

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