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Article

GINS4 suppresses ferroptosis by antagonizing p53 acetylation with Snail

5 Apr 2023

Abstract excerpt

Ferroptosis is an iron-dependent oxidative, nonapoptotic form of regulated cell death caused by the destruction of redox homeostasis. Recent studies have uncovered complex cellular networks that regulate ferroptosis. GINS4 is a promoter of eukaryotic G 1 /S - cell cycle as a regulator of initiation and elongation of DNA replication, but little is known about its impact on ferroptosis. Here, we found that GINS4...

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PMID: 37018198
DOI: 10.1073/pnas.2219585120

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