Clinical Validity of Plasma-Based Genotyping for Microsatellite Instability Assessment in Advanced GI Cancers: SCRUM-Japan GOZILA Substudy.

doi:10.1200/PO.21.00383

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Article

Clinical Validity of Plasma-Based Genotyping for Microsatellite Instability Assessment in Advanced GI Cancers: SCRUM-Japan GOZILA Substudy.

JCO precision oncology - 1 Feb 2022

Nakamura Yoshiaki, Okamoto Wataru, Denda Tadamichi, Nishina Tomohiro, Komatsu Yoshito, Yuki Satoshi, Yasui Hisateru, Esaki Taito, Sunakawa Yu, Ueno Makoto, Shinozaki Eiji, Matsuhashi Nobuhisa, Ohta Takashi, Kato Ken, Ohtsubo Koushiro, Bando Hideaki, Hara Hiroki, Satoh Taroh, Yamazaki Kentaro, Yamamoto Yoshiyuki, Okano Naohiro, Terazawa Tetsuji, Kato Takeshi, Oki Eiji, Tsuji Akihito, Horita Yosuke, Hamamoto Yasuo, Kawazoe Akihito, Nakajima Hiromichi, Nomura Shogo, Mitani Ryuta, Yuasa Mihoko, Akagi Kiwamu, Yoshino Takayuki

Abstract excerpt

PURPOSE: Circulating tumor DNA (ctDNA) genotyping may guide targeted therapy for patients with advanced GI cancers. However, no studies have validated ctDNA genotyping for microsatellite instability (MSI) assessment in comparison with a tissue-based standard. PATIENTS AND METHODS: The performance of plasma-based MSI assessment using Guardant360, a next-generation sequencing-based ctDNA assay, was compared with...

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PMID: 35188805
DOI: 10.1200/PO.21.00383
PMCID: PMC8974570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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