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Profiling host ANP32A splicing landscapes to predict influenza A virus polymerase adaptation

30 Jul 2019

Abstract excerpt

Species' differences in cellular factors limit avian influenza A virus (IAV) zoonoses and human pandemics. The IAV polymerase, vPol, harbors evolutionary sites to overcome restriction and determines virulence. Here, we establish host ANP32A as a critical driver of selection, and identify host-specific ANP32A splicing landscapes that predict viral evolution. We find that avian species differentially express three...

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PMID: 31363119
DOI: 10.1038/s41467-019-11388-2

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