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High endothelial venules are associated with microsatellite instability, hereditary background and immune evasion in colorectal cancer

29 Jul 2019

Abstract excerpt

Microsatellite-unstable (MSI) tumours show a high load of mutational neo antigens, as a consequence of DNA mismatch repair deficiency. Consequently, MSI tumours commonly present with dense immune infiltration and develop immune evasion mechanisms. Whether improved lymphocyte recruitment contributes to the pronounced immune infiltration in MSI tumours is unknown. We analysed the density of high endothelial venules...

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PMID: 31358939
DOI: 10.1038/s41416-019-0514-6

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