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Article

Tumor-intrinsic signaling pathways: key roles in the regulation of the immunosuppressive tumor microenvironment

27 Nov 2019

Abstract excerpt

Immunotherapy is a currently popular treatment strategy for cancer patients. Although recent developments in cancer immunotherapy have had significant clinical impact, only a subset of patients exhibits clinical response. Therefore, understanding the molecular mechanisms of immunotherapy resistance is necessary. The mechanisms of immune escape appear to consist of two distinct tumor characteristics: a decrease in...

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PMID: 31775797
DOI: 10.1186/s13045-019-0804-8

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