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Article

Perturbation of endoplasmic reticulum homeostasis facilitates prion replication.

The Journal of biological chemistry - 27 Apr 2007

Hetz Claudio, Castilla Joaquín, Soto Claudio

Abstract excerpt

Prion diseases are fatal and infectious neurodegenerative disorders characterized by the accumulation of an abnormally folded form of the prion protein (PrP), termed PrP(Sc). Prion replication triggers endoplasmic reticulum (ER) stress, neuronal dysfunction, and apoptosis. In this study we analyze the effect of perturbations in ER homeostasis on PrP biochemical properties and prion replication. ER stress led to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17329244
DOI: 10.1074/jbc.M611909200
PMCID: PMC2804266

Genes

ATF4
ATF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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