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Evaluating the role of ARSA in Chinese patients with Parkinson's disease.

Neurobiology of aging - 1 Jan 2022

Pan Hong-Xu, Wang Yi-Ge, Zhao Yu-Wen, Zeng Qian, Wang Zheng, Fang Zheng-Huan, Zhang Yi, Zhou Xun, He Run-Cheng, Xu Qian, Sun Qi-Ying, Tan Jie-Qiong, Yan Xin-Xiang, Li Jin-Chen, Tang Bei-Sha, Guo Ji-Feng

Abstract excerpt

Recent studies have suggested ARSA, a gene responsible for metachromatic leukodystrophy, could be a genetic modifier of Parkinson's disease (PD) pathogenesis, acting as a molecular chaperone for α-synuclein. To elucidate the role of ARSA variants in PD, we did a comprehensive analysis of ARSA variants by performing next-generation sequencing on 477 PD families, 1440 sporadic early-onset PD patients and 1962...

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PMID: 34531044
DOI: 10.1016/j.neurobiolaging.2021.08.008

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