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Regulatory mechanisms leading to differential Acyl-CoA synthetase 4 expression in breast cancer cells

16 Jul 2019

Abstract excerpt

Acyl-CoA synthetase 4 (ACSL4) overexpression plays a causal role in the aggressiveness of triple negative breast cancer. In turn, a negative correlation has been established between ACSL4 and estrogen receptor alpha (ERα) expression. However, the upstream regulatory mechanisms leading to differential ACSL4 expression between triple negative breast cancer and ERα-positive cells remained unknown. We performed the...

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PMID: 31311992
DOI: 10.1038/s41598-019-46776-7

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