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Article

p53 mutant-type in human prostate cancer cells determines the sensitivity to phenethyl isothiocyanate induced growth inhibition.

Journal of experimental & clinical cancer research : CR - 15 Jul 2019

Aggarwal Monika, Saxena Rahul, Asif Nasir, Sinclair Elizabeth, Tan Judy, Cruz Idalia, Berry Deborah, Kallakury Bhaskar, Pham Quynhchi, Wang Thomas T Y, Chung Fung-Lung

Abstract excerpt

BACKGROUND: We reported previously that phenethyl isothiocyanate (PEITC), a dietary compound, can reactivate p53R175H mutant in vitro and in SK-BR-3 (p53R175H) breast xenograft model resulting in tumor inhibition. Because of the diversity of human cancers with p53 mutations, these findings raise important questions whether this mechanism operates in different cancer types with same or different p53 mutations. In...

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Identifiers

PMID: 31307507
DOI: 10.1186/s13046-019-1267-z
PMCID: PMC6632191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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