Reactivation of P53 Antiproliferative and Pro-Apoptotic Pathways by Resveratrol in Mutant P53 Cancer Cell Lines.

Abstract excerpt

Cancer is the second leading cause of death worldwide. Mutations in the TP53 gene lead to a loss of tumor suppressor function and an oncogenic gain of function for the protein, resulting in a more invasive, metastatic, and chemoresistant phenotype. Diverse structural studies have demonstrated that mutant p53 core domain unfolding is not irreversible. Thus, reactivation toward its wild-type-like conformation or...

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