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Phenethyl isothiocyanate induces DNA damage-associated G2/M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations.

Free radical biology & medicine - 1 Sept 2014

Yeh Yao-Tsung, Yeh Hua, Su Shu-Hui, Lin Jian-Sheng, Lee Kuo-Jui, Shyu Huey-Wen, Chen Zi-Feng, Huang Sheng-Yun, Su Shu-Jem

Abstract excerpt

Phenethyl isothiocyanate (PEITC) is a naturally occurring cruciferous vegetable-derived compound that inhibits cell growth and induces apoptosis in oral cancer cells. However, the exact mechanism of PEITC action has not been fully elucidated. This study investigated the molecular mechanism and anticancer potential of PEITC in oral squamous cell carcinoma (OSCC) cells with various p53 statuses. PEITC inhibited the...

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PMID: 24952138
DOI: 10.1016/j.freeradbiomed.2014.06.008

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