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An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model

15 Mar 2017

Abstract excerpt

Abstract The Zika virus (ZIKV) outbreak in the Americas and South Pacific poses a significant burden on human health because of ZIKV’s neurotropic effects in the course of fetal development. Vaccine candidates against ZIKV are coming online, but immunological tools to study anti-ZIKV responses in preclinical models, particularly T cell responses, remain sparse. We deployed RNA nanoparticle technology to create a...

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PMID: 28325910
DOI: 10.1038/s41598-017-00193-w

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