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Development of a Novel System To Study Hepatitis Delta Virus Genome Replication

15 Jun 2005

Abstract excerpt

Hepatitis delta virus (HDV) genome replication requires the virus-encoded small delta protein (deltaAg). During replication, nucleotide sequence changes accumulate on the HDV RNA, leading to the translation of deltaAg species that are nonfunctional or even inhibitory. A replication system was devised where all deltaAg was conditionally provided from a separate and unchanging source. A line of human embryonic...

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Identifiers

PMID: 15956563
DOI: 10.1128/jvi.79.13.8182-8188.2005

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