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Article

The CspC pseudoprotease regulates germination of Clostridioides difficile spores in response to multiple environmental signals.

PLoS genetics - 1 Jul 2019

Rohlfing Amy E, Eckenroth Brian E, Forster Emily R, Kevorkian Yuzo, Donnelly M Lauren, Benito de la Puebla Hector, Doublié Sylvie, Shen Aimee

Abstract excerpt

The gastrointestinal pathogen, Clostridioides difficile, initiates infection when its metabolically dormant spore form germinates in the mammalian gut. While most spore-forming bacteria use transmembrane germinant receptors to sense nutrient germinants, C. difficile is thought to use the soluble pseudoprotease, CspC, to detect bile acid germinants. To gain insight into CspC's unique mechanism of action, we solved...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31276487
DOI: 10.1371/journal.pgen.1008224
PMCID: PMC6636752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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