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Revisiting the Role of Csp Family Proteins in Regulating Clostridium difficile Spore Germination

6 Sept 2017

Abstract excerpt

ABSTRACT Clostridium difficile causes considerable health care-associated gastrointestinal disease that is transmitted by its metabolically dormant spore form. Upon entering the gut, C. difficile spores germinate and outgrow to produce vegetative cells that release disease-causing toxins. C. difficile spore germination depends on the Csp family of (pseudo)proteases and the cortex hydrolase SleC. The CspC...

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PMID: 28874406
DOI: 10.1128/jb.00266-17

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