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Article

Reexamining the Germination Phenotypes of Several Clostridium difficile Strains Suggests Another Role for the CspC Germinant Receptor.

Journal of bacteriology - 14 Dec 2015

Bhattacharjee Disha, Francis Michael B, Ding Xicheng, McAllister Kathleen N, Shrestha Ritu, Sorg Joseph A

Abstract excerpt

UNLABELLED: Clostridium difficile spore germination is essential for colonization and disease. The signals that initiate C. difficile spore germination are a combination of taurocholic acid (a bile acid) and glycine. Interestingly, the chenodeoxycholic acid class (CDCA) bile acids competitively inhibit taurocholic acid-mediated germination, suggesting that compounds that inhibit spore germination could be...

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Source

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Identifiers

PMID: 26668265
DOI: 10.1128/JB.00908-15
PMCID: PMC4810609

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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