Article
Bacterial spore germination receptors are nutrient-gated ion channels.
Science (New York, N.Y.) - 28 Apr 2023
Gao Yongqiang, Amon Jeremy D, Artzi Lior, Ramírez-Guadiana Fernando H, Brock Kelly P, Cofsky Joshua C, Marks Deborah S, Kruse Andrew C, Rudner David Z
Abstract excerpt
Bacterial spores resist antibiotics and sterilization and can remain metabolically inactive for decades, but they can rapidly germinate and resume growth in response to nutrients. Broadly conserved receptors embedded in the spore membrane detect nutrients, but how spores transduce these signals remains unclear. Here, we found that these receptors form oligomeric membrane channels. Mutations predicted to widen the...
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