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Circulating Mitochondrial DNA is Linked to Progression and Prognosis of Epithelial Ovarian Cancer

1 Jul 2019

Abstract excerpt

As peripheral blood contains fluctuated levels of circulating cell-free mitochondrial DNA (ccf mtDNA), we aimed to evaluate ccf mtDNA as a biomarker for diagnosis and prognosis of epithelial ovarian cancer (EOC). In the present study, we recruited 165 EOC patients and 60 healthy women. Quantitative RT-PCR was applied to amplify 79-bp and 230-bp fragments of the mitochondrial 16 s RNA gene in sera of these...

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PMID: 31271962
DOI: 10.1016/j.tranon.2019.05.015

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