Article
Germline Pathogenic Variants in Cancer Predisposition Genes Among Women With Invasive Lobular Carcinoma of the Breast.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Dec 2021
Yadav Siddhartha, Hu Chunling, Nathanson Katherine L, Weitzel Jeffrey N, Goldgar David E, Kraft Peter, Gnanaolivu Rohan D, Na Jie, Huang Hongyan, Boddicker Nicholas J, Larson Nicole, Gao Chi, Yao Song, Weinberg Clarice, Vachon Celine M, Trentham-Dietz Amy, Taylor Jack A, Sandler Dale R, Patel Alpa, Palmer Julie R, Olson Janet E, Neuhausen Susan, Martinez Elena, Lindstrom Sara, Lacey James V, Kurian Allison W, John Esther M, Haiman Christopher, Bernstein Leslie, Auer Paul W, Anton-Culver Hoda, Ambrosone Christine B, Karam Rachid, Chao Elizabeth, Yussuf Amal, Pesaran Tina, Dolinsky Jill S, Hart Steven N, LaDuca Holly, Polley Eric C, Domchek Susan M, Couch Fergus J
Abstract excerpt
PURPOSE: To determine the contribution of germline pathogenic variants (PVs) in hereditary cancer testing panel genes to invasive lobular carcinoma (ILC) of the breast. MATERIALS AND METHODS: The study included 2,999 women with ILC from a population-based cohort and 3,796 women with ILC undergoing clinical multigene panel testing (clinical cohort). Frequencies of germline PVs in breast cancer predisposition genes...
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