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P53-regulated miR-320a targets PDL1 and is downregulated in malignant mesothelioma

14 Sept 2020

Abstract excerpt

Malignant pleural mesothelioma (MPM) is an aggressive cancer, related to asbestos exposure, which has a dismal prognosis. MPM diagnosis is late and often challenging, suggesting the need to identify more reliable molecular biomarkers. Here, we set out to identify differentially expressed miRNAs in epithelioid, biphasic, and sarcomatoid MPMs versus normal mesothelium and explored specific miRNA contribution to...

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PMID: 32929059
DOI: 10.1038/s41419-020-02940-w

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