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Article

Manipulating microRNAs for the Treatment of Malignant Pleural Mesothelioma: Past, Present and Future

7 Feb 2020

Abstract excerpt

MicroRNAs (miRNAs) are an important class of noncoding RNA that post-transcriptionally regulate the expression of most protein-coding genes. Their aberrant expression in tumours contributes to each of the hallmarks of cancer. In malignant pleural mesothelioma (MPM), in common with other tumour types, changes in miRNA expression are characterised by a global downregulation, although elevated levels of some miRNAs...

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PMID: 32117755
DOI: 10.3389/fonc.2020.00105

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