Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Roles of the Bcl-2/Bax Ratio, Caspase-8 and 9 in Resistance of Breast Cancer Cells to Paclitaxel

6 Nov 2014

Abstract excerpt

The goal of this study was to establish paclitaxel resistant MCF-7 cells, as in vitro model, to identify the molecular mechanisms leading to acquired chemoresistance in breast cancer cells. Resistant cells were developed by stepwise increasing exposure to paclitaxel. Gene expression levels of Bax and Bcl-2 along with protein levels of caspase-8 and caspase-9 were evaluated in two resistant cell lines (MCF...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell death mechanisms and regulation
Share to DNA Repair Mechanisms
Share to Drug Transport and Resistance Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25374178
DOI: 10.7314/apjcp.2014.15.20.8617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Roles of the Bcl-2/Bax Ratio, Caspase-8 and 9 in Resistance of Breast Cancer Cells to PaclitaxelPMID 25374178Read ↗

Alteration of the Mitochondrial Apoptotic Pathway Is Key to Acquired Paclitaxel Resistance and Can Be Reversed by ABT-737Semantic proximity Read ↗

The role of Six1 signaling in paclitaxel-dependent apoptosis in MCF-7 cell lineSemantic proximity Read ↗

Overcoming Drug Resistance by Enhancing Apoptosis of Tumor CellsSemantic proximity Read ↗

Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatmentSemantic proximity Read ↗

New Insights in Gene Expression Alteration as Effect of Paclitaxel Drug Resistance in Triple Negative Breast Cancer CellsSemantic proximity Read ↗

Molecular mechanisms of apoptosis and chemosensitivity to platinum and paclitaxel in ovarian cancer: biological data and clinical implications.Semantic proximity Read ↗

Mechanisms of cancer cell death induction by paclitaxel: an updated reviewSemantic proximity Read ↗

Key genes and molecular mechanisms related to Paclitaxel ResistanceSemantic proximity Read ↗

A Multistep Model for Paclitaxel-Induced Apoptosis in Human Breast Cancer Cell LinesSemantic proximity Read ↗

Resistance to paclitaxel therapy is related with Bcl-2 expression through an estrogen receptor mediated pathway in breast cancerSemantic proximity Read ↗

Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulationSemantic proximity Read ↗

Human breast cancer MCF-7 cell line contains inherently drug-resistant subclones with distinct genotypic and phenotypic features.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.