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Article

Clinical Implications of Identifying Pathogenic Variants in Individuals With Thoracic Aortic Dissection

1 Jun 2019

Abstract excerpt

BACKGROUND: Thoracic aortic dissection is an emergent life-threatening condition. Routine screening for genetic variants causing thoracic aortic dissection is not currently performed for patients or family members. METHODS: We performed whole exome sequencing of 240 patients with thoracic aortic dissection (n=235) or rupture (n=5) and 258 controls matched for age, sex, and ancestry. Blinded to case-control...

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PMID: 31211624
DOI: 10.1161/circgen.118.002476

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