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Exploring the genetic pathogenicity of aortic dissection from 72 Han Chinese individuals using next-generation sequencing.

Clinical genetics - 1 May 2020

Pan Meichen, Chen Shu, Wang Haihao, Wu Shifan, Ding Zijiao, Wang Yuning, Li Lianjie, Li Zehao, Liu Qian

Abstract excerpt

Aortic dissection (AD) is a heterogeneous genetic disease with high morbidity and mortality. Although many genes predispose patients to AD, the pathogenic spectrum remains incomplete. This study aims to (a) investigate whether genotype differences exist between Stanford A and B AD individuals, and (b) broaden the pathogenic genetic spectrum of AD and reported novel variants of AD-associated genes. The DNA of 72...

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PMID: 32154576
DOI: 10.1111/cge.13729

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