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Juniperonic Acid Biosynthesis is Essential in Caenorhabditis Elegans Lacking Δ6 Desaturase (fat-3) and Generates New ω-3 Endocannabinoids.

Cells - 19 Sept 2020

Guha Sujay, Calarco Serafina, Gachet M Salomé, Gertsch Jürg

Abstract excerpt

In eukaryotes, the C20:4 polyunsaturated fatty acid arachidonic acid (AA) plays important roles as a phospholipid component, signaling molecule and precursor of the endocannabinoid-prostanoid axis. Accordingly, the absence of AA causes detrimental effects. Here, compensatory mechanisms involved in AA deficiency in Caenorhabditis elegans were investigated. We show that the ω-3 C20:4 polyunsaturated fatty acid...

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PMID: 32961767
DOI: 10.3390/cells9092127
PMCID: PMC7564282

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