Back to search

Article

An Integrated Systems Biology Approach Identifies the Proteasome as a Critical Host Machinery for ZIKV and DENV Replication

2020-03-05

Abstract excerpt

The Zika (ZIKV) and dengue (DENV) flaviviruses exhibit similar replicative processes but distinct clinical outcomes. A systematic understanding of virus-host protein-protein interaction networks can reveal cellular pathways critical to viral replication and disease pathogenesis. Here we employed three independent systems biology approaches toward this goal. First, protein array analysis of direct interactions betw...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
860864b0-7ae8-55a5-86de-aaf1d9f88944
DOI
10.1101/2020.03.04.976548
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
An Integrated Systems Biology Approach Identifies the Proteasome as a Critical Host Machinery for ZIKV and DENV ReplicationDOI 10.1101/2020.03.04.976548
An Integrated Systems Biology Approach Identifies the Proteasome as a Critical Host Machinery for ZIKV and DENV ReplicationSemantic proximity
Quantitative Proteomic Analysis of Mosquito C6/36 Cells Reveals Host Proteins Involved in Zika Virus InfectionSemantic proximity
An orthogonal proteomic survey uncovers novel Zika virus host factorsSemantic proximity
The Unique Cofactor Region of Zika Virus NS2B–NS3 Protease Facilitates Cleavage of Key Host ProteinsSemantic proximity
Global Interactomics Uncovers Extensive Organellar Targeting by Zika VirusSemantic proximity
The current landscape of coronavirus-host protein–protein interactionsSemantic proximity
An evolutionarily conserved ubiquitin ligase drives infection and transmission of flavivirusesSemantic proximity
Virus-host interactomics: new insights and opportunities for antiviral drug discoverySemantic proximity
Envelope protein ubiquitination drives entry and pathogenesis of Zika virusSemantic proximity
Critical Nodes of Virus–Host Interaction Revealed Through an Integrated Network AnalysisSemantic proximity
Transcriptional and Translational Dynamics of Zika and Dengue Virus InfectionSemantic proximity
Identification of Zika Virus and Dengue Virus Dependency Factors using Functional GenomicsSemantic proximity
Select a neighboring publication to make it the new centre.