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Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics

1 Jun 2016

Abstract excerpt

The flaviviruses dengue virus (DENV) and Zika virus (ZIKV) are severe health threats with rapidly expanding ranges. To identify the host cell dependencies of DENV and ZIKV, we completed orthologous functional genomic screens using RNAi and CRISPR/Cas9 approaches. The screens recovered the ZIKV entry factor AXL as well as multiple host factors involved in endocytosis (RAB5C and RABGEF), heparin sulfation (NDST1...

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PMID: 27342126
DOI: 10.1016/j.celrep.2016.06.028

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