Article
Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability.
Molecular psychiatry - 1 Mar 2018
Duncan L E, Ratanatharathorn A, Aiello A E, Almli L M, Amstadter A B, Ashley-Koch A E, Baker D G, Beckham J C, Bierut L J, Bisson J, Bradley B, Chen C-Y, Dalvie S, Farrer L A, Galea S, Garrett M E, Gelernter J E, Guffanti G, Hauser M A, Johnson E O, Kessler R C, Kimbrel N A, King A, Koen N, Kranzler H R, Logue M W, Maihofer A X, Martin A R, Miller M W, Morey R A, Nugent N R, Rice J P, Ripke S, Roberts A L, Saccone N L, Smoller J W, Stein D J, Stein M B, Sumner J A, Uddin M, Ursano R J, Wildman D E, Yehuda R, Zhao H, Daly M J, Liberzon I, Ressler K J, Nievergelt C M, Koenen K C
Abstract excerpt
The Psychiatric Genomics Consortium-Posttraumatic Stress Disorder group (PGC-PTSD) combined genome-wide case-control molecular genetic data across 11 multiethnic studies to quantify PTSD heritability, to examine potential shared genetic risk with schizophrenia, bipolar disorder, and major depressive disorder and to identify risk loci for PTSD. Examining 20 730 individuals, we report a molecular genetics-based...
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