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MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling

8 Feb 2017

Abstract excerpt

Abstract The mitochondrial GTPase mitofusin-2 (MFN2) has previously been reported to play a role in regulating cell proliferation, apoptosis and differentiation in a number of cell types. Here, we report that breast cancer patients with low MFN2 expression are associated with poor prognosis as compared to patients with high MFN2 expression. We find that MFN2 knockout from MCF7 and A549 cells via Crispr/Cas9...

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PMID: 28176801
DOI: 10.1038/srep41718

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