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Article

Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson’s disease

23 Mar 2019

Abstract excerpt

The mechanism by which dopaminergic neurons are selectively affected in Parkinson's disease is not fully understood. In this study, we found a dramatic increase in the expression of catechol-O-methyltransferase (COMT), along with a lower level of DNA methylation, in induced pluripotent stem cell-derived dopaminergic neurons from patients with parkin (PARK2) gene mutations compared to those from healthy controls....

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PMID: 31135049
DOI: 10.1093/brain/awz084

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