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Article

Visualization of Cancer Cell-Derived Exosome-Induced Fibroblast Phenotypic Transformation.

Analytical chemistry - 8 Apr 2025

Yin Shuhang, Chen Feng, Peng Boru, Shi Yongyan, Lu Qiujun, Zhu Xiaohua, Li Haitao, Zhang Youyu

Abstract excerpt

Fibroblast phenotypic transformation plays a crucial role in tumorigenesis. Tumor cell-derived exosome-mediated fibroblast phenotypic transformation has been commonly studied. However, there is still no direct evidence that the process of tumor cell-derived exosomes induces the transformation of fibroblasts into cancer-associated fibroblasts (CAFs). Herein, exosomal miRNAs were used as a target to track the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40145678
DOI: 10.1021/acs.analchem.4c06175

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FAP

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