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Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors

17 Dec 2014

Abstract excerpt

Mammals express the sialic acids N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) on cell surfaces, where they act as receptors for pathogens, including influenza A virus (IAV). Neu5Gc is synthesized from Neu5Ac by the enzyme cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH). In humans, this enzyme is inactive and only Neu5Ac is produced. Ferrets are susceptible to...

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PMID: 25517696
DOI: 10.1038/ncomms6750

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