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Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis

27 May 2019

Abstract excerpt

Variability in bacterial sterilization is a key feature of Mycobacterium tuberculosis (Mtb) disease. In a population of human macrophages, there are macrophages that restrict Mtb growth and those that do not. However, the sources of heterogeneity in macrophage state during Mtb infection are poorly understood. Here, we perform RNAseq on restrictive and permissive macrophages and reveal that the expression of genes...

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PMID: 31133636
DOI: 10.1038/s41467-019-10065-8

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