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Article

Inhibition of RNA polymerase III transcription by Triptolide attenuates colorectal tumorigenesis

23 May 2019

Abstract excerpt

BACKGROUND: Upregulation of RNA polymerase (Pol) III products, including tRNAs and 5S rRNA, in tumor cells leads to enhanced protein synthesis and tumor formation, making it a potential target for cancer treatment. In this study, we evaluated the inhibition of Pol III transcription by triptolide and the anti-cancer effect of this drug in colorectal tumorigenesis. METHODS: The effect of triptolide on colorectal...

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PMID: 31122284
DOI: 10.1186/s13046-019-1232-x

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