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Coalescing replication compartments provide the opportunity for recombination between coinfecting herpesviruses

20 May 2019

Abstract excerpt

ABSTRACT Homologous recombination (HR) is considered a major driving force of evolution because it generates and expands genetic diversity. Evidence of HR between coinfecting herpesvirus DNA genomes can be found frequently both in vitro and in clinical isolates. Each herpes simplex virus type 1 (HSV‐1) replication compartment (RC) derives from a single incoming genome and maintains a specific territory within the...

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PMID: 31107607
DOI: 10.1096/fj.201900032r

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