Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes as a Model to Study Trypanosoma cruzi Infection

16 May 2019

Abstract excerpt

Chagas disease (ChD) is one of the most neglected tropical diseases, with cardiomyopathy being the main cause of death in Trypanosoma cruzi-infected patients. As the parasite actively replicates in cardiomyocytes (CMs), the heart remains a key target organ in the pathogenesis of ChD. Here we modeled ChD using human induced pluripotent stem cell-derived CMs (iPSC-CMs) to understand the complex interplay between...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Trypanosoma species research and implications

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 31105048
DOI: 10.1016/j.stemcr.2019.04.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes as a Model to Study Trypanosoma cruzi InfectionPMID 31105048Read ↗

Induced pluripotent stem cell-derived human macrophages as an infection model for <i>Trypanosoma cruzi</i>Semantic proximity Read ↗

Chagas Disease Cardiomyopathy: Immunopathology and GeneticsSemantic proximity Read ↗

Comparative Transcriptome Profiling of Human Foreskin Fibroblasts Infected with the Sylvio and Y Strains of Trypanosoma cruziSemantic proximity Read ↗

Cardiomyocyte transcriptomic signatures in response to <i>Trypanosoma cruzi</i> infection underpin Chagas cardiomyopathy progressionSemantic proximity Read ↗

Cardiac and Digestive Forms of Chagas Disease: An Update on Pathogenesis, Genetics, and Therapeutic TargetsSemantic proximity Read ↗

Generation of an induced pluripotent stem cell line (SYSUi005-A) from a patient with hypertrophic cardiomyopathy.Semantic proximity Read ↗

Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruziSemantic proximity Read ↗

Reduced levels of inositol hexakisphosphate kinase (IP6K) impair life-cycle transitions and the intracellular development of <i>Trypanosoma cruzi</i> within human cardiomyocytesSemantic proximity Read ↗

MicroRNA Transcriptome Profiling in Heart of Trypanosoma cruzi-Infected Mice: Parasitological and Cardiological OutcomesSemantic proximity Read ↗

The effects of inflammation on connexin 43 in chronic Chagas disease cardiomyopathySemantic proximity Read ↗

Trypanosoma cruzi Dysregulates piRNAs Computationally Predicted to Target IL-6 Signaling Molecules During Early Infection of Primary Human Cardiac FibroblastsSemantic proximity Read ↗

Transcriptome analysis of circulating microRNAs associated with Chagas disease susceptibility and chronic Chagas cardiomyopathy severitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.