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Article

The effects of inflammation on connexin 43 in chronic Chagas disease cardiomyopathy

29 Jul 2024

Abstract excerpt

Background Cardiac arrhythmias are the main cause of sudden death due to Chronic Chagasic Cardiomyopathy (CCC). Here we investigated alterations in connexin 43 (Cx43) expression and phosphorylation in cardiomyocytes as well as associations with cardiac arrhythmias in CCC. Methods C57Bl/6 mice infected with Trypanosoma cruzi underwent cardiac evaluations at 6 and 12 months after infection via treadmill testing and...

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PMID: 39136016
DOI: 10.3389/fimmu.2024.1440662

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