Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi

15 Jan 2016

Abstract excerpt

The molecular mechanisms of Trypanosoma cruzi induced cardiac fibrosis remains to be elucidated. Primary human cardiomyoctes (PHCM) exposed to invasive T. cruzi trypomastigotes were used for transcriptome profiling and downstream bioinformatic analysis to determine fibrotic-associated genes regulated early during infection process (0 to 120 minutes). The identification of early molecular host responses to T....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Galectins and Cancer Biology
Share to Research on Leishmaniasis Studies
Share to Trypanosoma species research and implications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26771187
DOI: 10.1371/journal.pntd.0003747

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruziPMID 26771187Read ↗

Gene Expression Changes Associated with Myocarditis and Fibrosis in Hearts of Mice with Chronic Chagasic CardiomyopathySemantic proximity Read ↗

Immunologic changes are detectable in the peripheral blood transcriptome of clinically asymptomatic Chagas cardiomyopathy patientsSemantic proximity Read ↗

Integration of miRNA and gene expression profiles suggest a role for miRNAs in the pathobiological processes of acute Trypanosoma cruzi infectionSemantic proximity Read ↗

Early<i>Trypanosoma cruzi</i>Infection Reprograms Human Epithelial CellsSemantic proximity Read ↗

Correlation of blood-based immune molecules with cardiac gene expression profiles reveals insights into Chagas cardiomyopathy pathogenesisSemantic proximity Read ↗

miRNAs may play a major role in the control of gene expression in key pathobiological processes in Chagas disease cardiomyopathySemantic proximity Read ↗

Blood Gene Signatures of Chagas Cardiomyopathy With or Without Ventricular DysfunctionSemantic proximity Read ↗

Trypanosoma cruzi Dysregulates piRNAs Computationally Predicted to Target IL-6 Signaling Molecules During Early Infection of Primary Human Cardiac FibroblastsSemantic proximity Read ↗

Transcriptomic alterations in Trypanosoma cruzi-infected cardiac myocytesSemantic proximity Read ↗

Cardiomyocyte transcriptomic signatures in response to <i>Trypanosoma cruzi</i> infection underpin Chagas cardiomyopathy progressionSemantic proximity Read ↗

Comparative Transcriptome Profiling of Human Foreskin Fibroblasts Infected with the Sylvio and Y Strains of Trypanosoma cruziSemantic proximity Read ↗

Differential expression profile of genes involved in the immune response associated to progression of chronic Chagas diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.