Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human TRA2A determines influenza A virus host adaptation by regulating viral mRNA splicing

17 Jun 2020

Abstract excerpt

Several avian influenza A viruses (IAVs) have adapted to mammalian species, including humans. To date, the mechanisms enabling these host shifts remain incompletely understood. Here, we show that a host factor, human TRA2A (huTRA2A), inhibits avian IAV replication, but benefits human IAV replication by altered regulation of viral messenger RNA (mRNA) splicing. huTRA2A depresses mRNA splicing by binding to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Influenza Virus Research Studies
Share to interferon and immune responses
Share to RNA and protein synthesis mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32596447
DOI: 10.1126/sciadv.aaz5764

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human TRA2A determines influenza A virus host adaptation by regulating viral mRNA splicingPMID 32596447Read ↗

Influenza Viruses and mRNA Splicing: Doing More with LessSemantic proximity Read ↗

hnRNPM regulates influenza A virus replication through distinct mechanisms in human and avian cells: implications for cross-species transmissionSemantic proximity Read ↗

A comprehensive study on cellular RNA editing activity in response to infections with different subtypes of influenza a virusesSemantic proximity Read ↗

RNA virus infections and their effect on host alternative splicingSemantic proximity Read ↗

Profiling host ANP32A splicing landscapes to predict influenza A virus polymerase adaptationSemantic proximity Read ↗

Direct RNA Sequencing Reveals m6A Modifications and Isoform Changes in SARS-CoV-2-Infected HEK CellsSemantic proximity Read ↗

Direct RNA Sequencing Reveals m6A Modifications and Isoform Changes in SARS-CoV-2-Infected HEK CellsSemantic proximity Read ↗

Functional Insights into ANP32A-Dependent Influenza A Virus Polymerase Host RestrictionSemantic proximity Read ↗

Host Non-Coding RNA Regulates Influenza A Virus ReplicationSemantic proximity Read ↗

N6-methyladenosine promotes induction of ADAR1-mediated A-to-I RNA editing to suppress aberrant antiviral innate immune responsesSemantic proximity Read ↗

Existing Evidence for Influenza B Virus Adaptations to Drive Replication in Humans as the Primary HostSemantic proximity Read ↗

Influenza A virus avian-derived PB1 gene has evolved to match its codon usage to interferon-altered human tRNA poolsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.