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Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication

10 Feb 2023

Abstract excerpt

Orthomyxo- and bunyaviruses steal the 5′ cap portion of host RNAs to prime their own transcription in a process called “cap snatching.” We report that RNA modification of the cap portion by host 2′-O-ribose methyltransferase 1 (MTr1) is essential for the initiation of influenza A and B virus replication, but not for other cap-snatching viruses. We identified with in silico compound screening and functional...

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PMID: 36758070
DOI: 10.1126/science.add0875

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