Article
In vitro models for gluten toxicity: relevance for celiac disease pathogenesis and development of novel treatment options.
Experimental biology and medicine (Maywood, N.J.) - 1 Feb 2012
Lindfors Katri, Rauhavirta Tiina, Stenman Satumarja, Mäki Markku, Kaukinen Katri
Abstract excerpt
In genetically predisposed individuals, dietary gluten in wheat, rye and barley triggers celiac disease, a systemic autoimmune disorder hallmarked by an extensive small-bowel mucosal immune response. The current conception of celiac disease pathogenesis is that it involves components of both innate and adaptive immunity whose activation typically leads to small-bowel villous atrophy with crypt hyperplasia....
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