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Article

Myeloid somatic mutation panel testing in myeloproliferative neoplasms.

Pathology - 1 Apr 2021

Ross David M, Thomson Candice, Hamad Nada, Lane Steven W, Manos Kate, Grigg Andrew P, Guo Belinda, Erber Wendy N, Scott Ashleigh, Viiala Nick, Chee Lynette, Latimer Maya, Tate Courtney, Grove Carolyn, Perkins Andrew C, Blombery Piers

Abstract excerpt

Myeloproliferative neoplasms are characterised by somatic mutations in pathways that regulate cell proliferation, epigenetic modifications, RNA splicing or DNA repair. Assessment of the mutational profile assists diagnosis and classification, but also aids assessment of prognosis, and may guide the use of emerging targeted therapies. The most practical way to provide information on numerous genetic variants is by...

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PMID: 33674147
DOI: 10.1016/j.pathol.2021.01.003

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