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Article

FAM64A positively regulates STAT3 activity to promote Th17 differentiation and colitis-associated carcinogenesis

6 May 2019

Abstract excerpt

STAT3 is a transcription factor that plays central roles in various physiological processes, including differentiation of Th cells. Its deregulation results in serious diseases, including inflammatory diseases and cancer. The mechanisms related to how STAT3 activity is regulated remain enigmatic. Here we show that overexpression of FAM64A potentiates IL-6-induced activation of STAT3 and expression of downstream...

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PMID: 31061131
DOI: 10.1073/pnas.1814336116

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