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Article

Patterns of substrate affinity, competition, and degradation kinetics underlie biological activity of thalidomide analogs

1 May 2019

Abstract excerpt

Abstract Pharmacologic agents that modulate ubiquitin ligase activity to induce protein degradation are a major new class of therapeutic agents, active in a number of hematologic malignancies. However, we currently have a limited understanding of the determinants of activity of these agents and how resistance develops. We developed and used a novel quantitative, targeted mass spectrometry (MS) assay to determine...

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Share to Multiple Myeloma Research and Treatments
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Share to Ubiquitin and proteasome pathways

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Identifiers

PMID: 31043423
DOI: 10.1182/blood.2019000789

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